Mental Health: The Neurotransmitter Edition

Brain and mental health concerns affect a huge number of people. Where does it all come from? Does it start or continue because of the way the brain and nervous system is working?

Natural Brain Chemicals and Your Mood

Some of it is genetic, passed down from our families. Some of it is triggered by stress and/or traumatic life events. Many times, it seems to be related to “brain chemicals” called neurotransmitters. Most likely, it’s a complex combination of many of these, plus other factors!

Today we’re talking neurotransmitters and their roles in mental health for stress and mood.

Plus, I’ll let you in on what doesn’t work, as well as one major thing you can do to help to boost your brain health, mental health (and neurotransmitters)!

Neuro-what? (Neurotransmitters)

Our nerves are one of the main communication systems in our body. The whole nervous system including our brain, spinal cord, nerve cells and a few other key cells is sometimes called the “master communication system of the body.”

Ever wonder how these cells communicate and what this may have to do with mental health and brain health?

This is where “neurotransmitters” come in. They are “brain chemicals” made from protein. Neurotransmitters do exactly that - they transmit information between nerve cells. They help our neurons “talk” to each other.

FUN FACT: Nerve cells are called “neurons.” Our nervous system has other types of cells as well.

We have billions of neurons in our body. About 100 billion of them are in our brains and there are billions more in our spinal cords and the rest of our bodies. Neurons relay messages from our brain and spinal cord (central nervous system) to our big toes, everywhere else in our bodies and then all the way back to our brain.

“All sensations, movements, thoughts, memories and feelings are the result of signals that pass-through neurons.” (NIH)

Therefore, the research into neurotransmitters is so very important when it comes to brain and mental health!

How Neurotransmitters Work

Neurons use both electrical and chemical signals to transmit messages. A neuron is a nerve cell with a long tail-like end called a “dendrite.” When it gets a message, it sends the signal from one end of the tail all the way down to the other end of the cell via electricity. It cannot, however, send its electrical signal through to its neighboring neuron. To send that message over, it communicates with its neighboring neuron via neurotransmitters.

Here's How it Works

NOTE: Think of the game “hot potato” where people are in a line or a circle beside each other. The first person gets the “hot potato” and needs to pass it to their neighbor. This must continue as quickly as possible until the potato gets to the right place.

In real life, a neuron gets a signal, say you touch something hot. Let’s consider this “hot” signal the “hot potato.” That neuron in your finger gets the message and needs to quickly send it through the communication network all the way to the spinal cord or brain.

It first sends the signal as an electrical signal through its “tail” all the way to its other end. Think of this as the first person holding the potato and turning toward their neighbor while still holding the potato. In your neurons this is done electrically, so while the potato is in someone’s hands it’s like the electrical signal going from one side to the other.

That one neuron doesn’t reach all the way where the signal needs to go - it needs to get to your spinal cord or brain. So, it must relay that signal to its neighboring neuron. Here’s where it passes the “potato” to the neighbor. The problem is that it can’t pass the electricity. So, it must change that signal into a chemical to get to the neighboring cell. This is where neurotransmitters come into the game.

The neurotransmitter goes through the tiny space between the two cells called a “synapse.” When that neurotransmitter reaches that neighboring neuron, it attaches to a “receptor.” That receptor is the neighbor’s hands that catch that “hot potato.” When that neurotransmitter gets to that second cell, it then changes the chemical signal back into an electrical one.

This electrical-chemical communication happens quickly and continues until the message gets to where it needs to go. From your fingertip up to your spinal cord or brain where a super-quick decision is made. Then another signal goes back down to your finger to move the muscles to quickly pull it away from the pain.

This is how our nervous system is the master communication system of the body! It’s how our brain knows if it should be awake (because of the light your eyes see), whether you’re too hot (and need to sweat to cool off), or whether you’re in danger (and need to “fight or flee”).

Key Neurotransmitters

There are many different neurotransmitters. Let’s look at three key ones and what we know so far about their roles in stress and moods.

Key Neurotransmitter #1 - Serotonin (“happy”)

Serotonin, also known as 5-hydroxytryptamine, has many roles in the nervous system. It’s involved with maintaining our body temperature and is transformed into melatonin to help us get sleepy when the light starts to dim. It’s also important for our memory, our stress response, as well as processing our emotions.

Serotonin is made from the amino acid (one of the building blocks of protein) called tryptophan. Due to its role in mental health, many medications for depression target the serotonin that is produced in the brain.

Some serotonin is made in the brain, but most of it is made in the gut. One of serotonin’s roles in the gut is to help our gut keep food moving through it (“gastric motility”). This goes to show how important a healthy gut is for your brain health!

Key Neurotransmitter #2 - Norepinephrine (NE) (“alertness” and “stress”)

Norepinephrine (NE) is a neurotransmitter released in brain and is involved in the stress response. If you’ve heard of “adrenaline,” and the adrenaline rush of being on a rollercoaster or bungee jumping, you’ve heard of epinephrine. Epinephrine is another name for adrenaline. It’s a huge part of our “fight or flight” reaction.

The part of our nervous system that is activated when we’re stressed and when we feel anxious results in a rapid release of norepinephrine in the brain.

Norepinephrine is made from the third neurotransmitter featured here called dopamine.

Key Neurotransmitter #3 - Dopamine (DA) (“motivation” and “behavior”)

Dopamine (DA) is the “motivation” neurotransmitter - it helps us to seek reward. Dopamine helps to turn our enjoyment of a reward into the desire to go out and get that reward. In this way it’s thought that dopamine helps to shape behavior. Some medications used to treat behavioral disorders work by changing how dopamine acts in the brain.

This “motivation” role of dopamine is also involved in our moods. For example, when dopamine levels are low, we can experience “anhedonia” which is when we lose our motivation to seek out reward.

Dopamine has other roles in brain and nervous system communication. It’s important for working memory and mental flexibility. It also helps to control our movement. For example, when certain parts of the brain don’t have enough dopamine, it can result in the muscular rigidity of Parkinson’s disease.

Dopamine is made from the amino acid called “tyrosine.”

Neurotransmitters and Stress

Stress is anything that challenges our body’s ability to maintain optimal health and have all our systems balanced. This goes for mental health (psychological stress) as well as physical stress (i.e., exercise and/or being cold).

Our natural physical and mental reactions to stress are for our own survival. Psychological stress can trigger our brain to react to danger. Our “fight or flight” response happens whether we’re scared because we’re on a roller coaster, we almost got in a car accident or whether we’re overworked and worried about our jobs. These are all examples of psychological stress, and they all cause the same response in the brain and the body.

Neurotransmitters and Mental Health

Depression and anxiety are some of the most common mental health concerns in the world. Many people experience both, and women are more likely than men to be diagnosed. In the next 13 years, depression may become the leading cause of disability in North America.

Depression involves a persistent feeling of sadness and loss of interest, empty or irritable mood that can significantly affect someone’s ability to function. Sometimes there are sleep issues, lack of energy as well as effects on appetite and anhedonia (a lack of motivation to seek out things that used to interest us or make us happy). Depression affects how someone feels, thinks and behaves. The symptoms might differ from person to person.

NOTE: If you think you may have depression, anxiety, or any brain or mental health concern, please see your licensed healthcare professional.

The causes of depression seem to be very complex, with many possible reasons that are unique to everyone. Reasons like genetics, hormones, stress and emotional loss may all contribute to the risk of depression.

A lot of research has looked at the structure and function of the brain to understand how it controls mood and emotions. One of the most popular ideas that started in the 1950s relates to neurotransmitters. The idea (or “hypothesis”) is that a deficiency in the “happy” neurotransmitter serotonin and the “stress” neurotransmitter norepinephrine is one reason for depression. Over the years, a possible role of dopamine has been added to this concept of depression.

When it comes to serotonin, it’s thought that not having enough serotonin in the right spots is one of the contributors. Due to its role in mood, many medications for depression target this neurotransmitter. Some newer medications also target norepinephrine and/or dopamine. It’s known that some people benefit from these medications, but others do not get better.

Exercise for Brain and Mental Health

Back in 1969, a researcher (Morgan) found that physically unfit people were more depressed than “fit” people. This study was the first to look at the links between exercise and mental health. It was groundbreaking at the time and sparked decades of research. We’re learning more and more about the effects physical exercise has on the functions of our brains and our moods.

Regular exercise reduces symptoms or slows progression of stress, depression, anxiety, dementia, Alzheimer’s, Parkinson’s and autism. Some studies show that, for certain types of depression, regular exercise may be as effective as medication or psychological therapy.

Both strength training and aerobic training have been shown to have positive effects on people with depression. Some researchers say that moderate-intensity aerobic training and high-intensity strength training may be the most effective exercises to provide positive mental and brain health benefits.

Exercise and Your Neurotransmitters

If exercise can help with brain and mental health, what does this have to do with neurotransmitters?

Regular exercise can protect the nervous system and increase metabolism, oxygenation and blood flow to the brain. Exercise also improves our mood by activating certain areas of the brain and induces the release of neurotransmitters and other brain chemicals. These chemicals can motivate us to continue to exercise regularly, helps to stimulate new neurons and can result in improved neuroplasticity (the ability of the brain to change itself). People who exercise tend to have lower levels of the stress hormone called cortisol than sedentary people. All of these are positive for both brain health and mental health.

Animal studies show that exercise increases the feel-good brain chemicals called “endorphins,” and affects the production and release of those three key neurotransmitters we talked about:

  • Serotonin (happy)
  • Norepinephrine (alertness and stress)
  • Dopamine (motivation and behavior)

In rodents, certain parts of the brain have higher levels of serotonin after exercise. Frequent exercise increases the amount of serotonin produced and used in the brain. Similarly with dopamine - exercise increases dopamine levels in different parts of animal brains.

While regular exercise can promote mental health. Excessive exercise and overtraining, on the other hand, can have adverse effects. If there is a lot of pressure to perform well, this can be detrimental to mental health and has been seen among elite athletes.

Supplements that Support Neurotransmitters

Some of the best supplements that can aid in the both the production and usage of neurotransmitters are the B vitamins. Taking a methylated B vitamin daily such as this one has been found by many people to increase energy, mood and motivation. B vitamins also play a critical role in the production of hormones and support the nervous system.

5-HTP, an amino acid that directly converts into Serotonin is a supplement that has been of tremendous help to those that are struggling with depression. (NOTE: 5 HTP should not be taken with pharmaceutical anti-depressants).

Focus Plus is a highly specialized supplement that was formulated for those with low Dopamine levels. It helps to correct low Dopamine symptoms such as low motivation, feelings of overwhelm, depression and difficulty concentrating.


Neurotransmitters are key chemicals our neurons use to communicate with each other. They are made from amino acids and are essential for optimal brain and mental health.

Regular exercise is a way to help boost our moods and ability to think and remember well. Exercise does this through improving the blood and oxygen flow to the brain, stimulation of our brains’ ability to change itself, as well as has positive effects on brain chemicals including neurotransmitters.

To determine your specific neurotransmitter levels there are a couple of ways to test as follows:

  1. Organic acids testing (OAT) - the OAT is one of the best functional medicine tests that is available. There are 76 different markers that are tested and the neurotransmitters are one part of this panel. You can read more about the OAT here.
  2. Neurotransmitter Profile - Genetics, environment, chemicals and nutritional deficiencies are a few factors that can impact neurotransmitter production. Once out of balance, the nervous system begins to compensate – which, in time, can lead to neurological or psychological symptoms.

Some of the more common psychological conditions today are known to be accompanied by neurotransmitter imbalances. However, it’s also possible for individuals to present with similar symptoms yet have unique foundational imbalances. Testing helps clarify these root issues.

The NeuroAdvanced Profile Includes the following neurotransmitters – GABA, Glutamine, Glycine, DA, Epinephrine, Norepinephrine, Histamine, Serotonin, PEA, DOPAC, HVA, 5-HIAA, NMN, VMA & Creatinine